Originally developed in Europe in the 1930s, it was introduced in the United States in the 1960s, but over the last 20 years it has become more prevalent within the pharmaceutical industry, and it is now widely considered to be the superior form of aseptic processing by various medicine regulatory agencies including the U.S. Food and Drug Administration (FDA) in the packaging of pharmaceutical and healthcare products.

Blow fill seal technology reduces personnel intervention making it a more robust method for the aseptic preparation of sterile pharmaceuticals.

Today SIG comprises one division: SIG Combibloc, specializing in aseptic carton.

In 1989, through the acquisition of PKL in Linnich, Germany, SIG entered the field of aseptic liquid packaging.

Aseptic liquid packaging remained separate under SIG Combibloc.

Today Combibloc is the last remaining business unit of SIG, its sole focus being machinery/materials for aseptic carton packaging.