Subsequent investigations by the Securities and Exchange Commission, Food and Drug Administration, London Stock Exchange and the European Medicines Evaluation Agency found that British Biotech had wilfully misled the public about the progress of marimastat and that unblinding data before the end of clinical trials does not necessarily invalidate the results.

Longrich and colleagues (2011) doubted this assessment, noting that there is the possibility that the bones belonged to a juvenile, but also noted that it was not impossible for some "archaic" birds to have persisted beyond the Cretaceous period for some time, and that this did not invalidate the hypothesis that birds experienced a mass extinction event at the end of the Mesozoic.

This negative attitude towards patents led to the inception of the Sherman Antitrust Act. During the depression, many opposed patents, and this is depicted in the tendency of courts to invalidate patents.

An incorrect listing of inventors may incurably invalidate any patent that might result from an application.

Also it does not invalidate any existing international convention or treaty which may be applicable abroad.

It should also be noted that the technique will not work for data that contains pointers, because any writer could invalidate a pointer that a reader has already followed.

The Act does not invalidate agreements made with false advertising, so even if a company does violate the Act, any contracts would still be valid.

Both analyses make simplifying assumptions (such as the assumption that there is zero cost of unwinding the fixed leg of the swap on default), which may invalidate the no-arbitrage assumption.

He was known for his strong use of substantive due process to invalidate regulations of business and property.