To reconcile the indifference and contingency of human actions with prescience; or to defend absolute decrees, and yet free the Deity from being the author of sin, has been found hitherto to exceed all the power of philosophy.

For such is the wonderful skill, prescience of experience, and invincible confidence acquired by some great natural geniuses among the Nantucket commanders; that from the simple observation of a whale when last descried, they will, under certain given circumstances, pretty accurately foretell both the direction in which he will continue to swim for a time, while out of sight, as well as his probable rate of progression during that period.

Humans mutated through the consumption of and exposure to massive amounts of the spice melange, Navigators are able to use a limited form of prescience to safely navigate interstellar space.

To enable their prescience, Guild Navigators not only consume large quantities of the spice, but are also continuously immersed in highly-concentrated amounts of orange spice gas.

The very first Navigator, Norma pioneers the use of melange to develop the prescience necessary to safely guide a spaceship through foldspace.

In "", D'murr is piloting one of two heighliners which Hasimir Fenring uses to secretly test the synthetic melange created by the Tleilaxu in their Project Amal. The flawed spice disrupts and confuses D'murr's thoughts, feelings and prescience.

Mary Stainbank displayed a remarkable prescience about the church and village as it would become post-Apartheid, especially once the demographics of Maidstone changed with the selling off of its property by the Tongaat-Hulett company.

Thirty years after the speech, Edward Heath said that Powell's remarks on the "economic burden of immigration" had been "not without prescience."

However, this kind of prescience is the exception, rather than the rule.

With prescience, Hoopes had observed: “Sassone’s art has evolved from within, and such an organic, psychological and spiritual process may take his work along new and unforeseen paths.” By the late eighties, Sassone had become increasingly concerned with social themes.